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Igor V Peshenko Selected Research

Guanylate Cyclase-Activating Proteins

1/2020Two clusters of surface-exposed amino acid residues enable high-affinity binding of retinal degeneration-3 (RD3) protein to retinal guanylyl cyclase.
1/2019Retinal degeneration 3 (RD3) protein, a retinal guanylyl cyclase regulator, forms a monomeric and elongated four-helix bundle.
1/2018GUCY2D Cone-Rod Dystrophy-6 Is a "Phototransduction Disease" Triggered by Abnormal Calcium Feedback on Retinal Membrane Guanylyl Cyclase 1.
1/2016Functional Study and Mapping Sites for Interaction with the Target Enzyme in Retinal Degeneration 3 (RD3) Protein.
1/2012Enzymatic relay mechanism stimulates cyclic GMP synthesis in rod photoresponse: biochemical and physiological study in guanylyl cyclase activating protein 1 knockout mice.
1/2010Mg2+/Ca2+ cation binding cycle of guanylyl cyclase activating proteins (GCAPs): role in regulation of photoreceptor guanylyl cyclase.

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Igor V Peshenko Research Topics

Disease

9Blindness (Hysterical Blindness)
10/2021 - 08/2015
8Retinal Degeneration
10/2021 - 08/2007
5Leber Congenital Amaurosis
03/2015 - 02/2010
4Cone-Rod Dystrophies
12/2020 - 11/2016
2Retinal Dystrophies
01/2021 - 02/2010
2type 1 Amaurosis congenita of Leber
01/2016 - 01/2013
2Retinal Diseases
04/2014 - 01/2012
1Retinal cone dystrophy 2
10/2021
1congenital stationary Night blindness
12/2020
1Night Blindness (Nyctalopia)
12/2020
1Photophobia (Light Sensitivity)
01/2010
1Mitochondrial Diseases (Mitochondrial Disease)
10/2003
1Cataract (Cataracts)
10/2003

Drug/Important Bio-Agent (IBA)

18Retinaldehyde (Retinal)IBA
10/2021 - 08/2007
17Guanylate Cyclase (Guanylyl Cyclase)IBA
10/2021 - 08/2007
14Proteins (Proteins, Gene)FDA Link
10/2021 - 11/2011
8CalciumIBA
10/2021 - 01/2012
6Guanylate Cyclase-Activating ProteinsIBA
01/2020 - 01/2010
3IsoenzymesIBA
10/2021 - 01/2012
2EnzymesIBA
01/2016 - 04/2014
2Phosphotransferases (Kinase)IBA
03/2015 - 02/2010
1Staphylococcal Protein A (Protein A)IBA
01/2019
1Carrier Proteins (Binding Protein)IBA
11/2011
1N-acetyl-4-benzoquinoneimine (NAPQI)IBA
10/2003
1CalpainIBA
10/2003
1Peptide Hydrolases (Proteases)FDA Link
10/2003
1Acetaminophen (Paracetamol)FDA LinkGeneric
10/2003
1calpain inhibitorsIBA
10/2003

Therapy/Procedure

1Therapeutics
01/2013
1Intraperitoneal Injections
10/2003